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indoline-4-ol

  • CAS：85926-99-4
  • purity：99%
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Chinese Factory Supply Wholesale indoline-4-ol 85926-99-4 with Cheap Price

  • Molecular Formula: C8H9NO
  • Molecular Weight: 135.166
  • Vapor Pressure: 0.00216mmHg at 25°C 
  • Melting Point: 139-140℃ 
  • Boiling Point: 280.9°Cat760mmHg 
  • Flash Point: 160.2°C 
  • PSA： 32.26000 
  • Density: 1.196g/cm3 
  • LogP: 1.49820 

indoline-4-ol(Cas 85926-99-4) Usage

General Description

Indoline-4-ol, also known as Oxindole, is a chemical compound belonging to the group of indolines, which are nitrogenous heterocyclic compounds. It is used greatly in the process of producing medication, primarily because of its ability to act as an inhibitor for a variety of enzymes. Consequently, it has potential anti-cancer properties and it can also influence the immune system. It exists in various modified forms which can have different biomedical applications, enhancing its versatility in medical and chemical research. Its formulation is usually in a liquid state and it requires careful handling due to its moderately toxic characteristics.

InChI:InChI=1/C8H9NO/c10-8-3-1-2-7-6(8)4-5-9-7/h1-3,9-10H,4-5H2

85926-99-4 Relevant articles

550 nm excited rhodamine dye and preparation method thereof

-

Paragraph 0032-0037; 0051-0055, (2020/07/12)

The invention provides 550 nm excited rh...

Design, synthesis and characterization of potent microtubule inhibitors with dual anti-proliferative and anti-angiogenic activities

Zhang, Huijun,Fang, Xiong,Meng, Qian,Mao, Yujia,Xu, Yan,Fan, Tingting,An, Jing,Huang, Ziwei

supporting information, p. 380 - 396 (2018/08/17)

Microtubule has been an important target...

INDOLE, INDOLINE DERIVATIVES, COMPOSITIONS COMPRISING THEM AND USES THEREOF

-

Page/Page column 26; 54; 89, (2013/10/22)

The invention provides indole and indoli...

Carbamate derivatives of indolines as cholinesterase inhibitors and antioxidants for the treatment of Alzheimer's disease

Yanovsky, Inessa,Finkin-Groner, Efrat,Zaikin, Andrey,Lerman, Lena,Shalom, Hila,Zeeli, Shani,Weill, Tehilla,Ginsburg, Isaac,Nudelman, Abraham,Weinstock, Marta

supporting information, p. 10700 - 10715 (2013/02/22)

The cascade of events that occurs in Alz...

85926-99-4 Process route

1H-indol-4-ol
2380-94-1

1H-indol-4-ol

4-hydroxyindoline
85926-99-4

4-hydroxyindoline

Conditions
Conditions Yield
1H-indol-4-ol; With sodium cyanoborohydride; acetic acid; at 15 - 20 ℃; for 1.5h;
With sodium hydrogencarbonate; In water; ethyl acetate;
100%
With sodium cyanoborohydride; In acetic acid; at 15 - 20 ℃; for 1.5h;
100%
With sodium cyanoborohydride; In acetic acid; at 15 - 20 ℃;
99%
With sodium cyanoborohydride; acetic acid; at 0 - 20 ℃; for 1h;
92%
With sodium cyanoborohydride; In acetic acid; at 0 - 20 ℃; for 3h; Inert atmosphere;
59%
With sodium cyanoborohydride; acetic acid; at 20 ℃;
32%
With hydrogen; palladium/alumina; at 125 ℃; for 16h; under 52505.3 Torr;
2-(2,6-diaminophenyl)ethanol
118742-89-5

2-(2,6-diaminophenyl)ethanol

4-hydroxyindoline
85926-99-4

4-hydroxyindoline

Conditions
Conditions Yield
With phosphoric acid; at 220 ℃; for 24h;
90%
Multi-step reaction with 2 steps
1: 92 percent / aq. 30percent H2 SO4 / 24 h / 170 °C
2: 86 percent / aq. 30percent H3 PO4 / 24 h / 220 °C
With phosphoric acid; sulfuric acid;

85926-99-4 Upstream products

  • 496-15-1
    496-15-1

    1-indoline

  • 52537-01-6
    52537-01-6

    4-aminoindoline

  • 118742-89-5
    118742-89-5

    2-(2,6-diaminophenyl)ethanol

  • 606-20-2
    606-20-2

    2,6-dinitrotoluene

85926-99-4 Downstream products

  • 2380-94-1
    2380-94-1

    1H-indol-4-ol

  • 737816-53-4
    737816-53-4

    4-acetoxy-1-acetylindoline

  • 1452925-60-8
    1452925-60-8

    C15 H15 NO3 S

  • 1452925-64-2
    1452925-64-2

    3-(7-bromo-4-hydroxy-1-tosylindolin-5-yl)propanoic acid

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