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2-[2-(2-methoxyethoxy)ethoxy]ethylamine Good Supplier In Bulk Supply High Purity 74654-07-2
- Molecular Formula: C7H17 N O3
- Molecular Weight: 163.217
- Vapor Pressure: 0.0939mmHg at 25°C
- Refractive Index: 1.4395 (589.3 nm 20℃)
- Boiling Point: 106℃ (11 Torr)
- PKA: 8.74±0.10(Predicted)
- Flash Point: 86.1°C
- PSA： 53.71000
- Density: 0.978g/cm3
- LogP: 0.32500
2-[2-(2-methoxyethoxy)ethoxy]ethylamine(Cas 74654-07-2) Usage
|
Synthesis |
2-[2-(2-methoxyethoxy)ethoxy]ethylamine is an organic intermediate, which can be prepared from triethylene glycol monomethyl ether as raw material to prepare 2-(2-(2-methoxyethoxy)ethoxy)ethyl 4-methylbenzenesulfonate, and then Reaction with sodium azide,and then Reacts with sodium azide to finally yield 3,6,9-trioxa-1-aminodecane. |
InChI:InChI=1/C7H17NO3/c1-9-4-5-11-7-6-10-3-2-8/h2-8H2,1H3
74654-07-2 Relevant articles
Non-invasive, real-time reporting drug release in vitro and in vivo
Zhang, Yanfeng,Yin, Qian,Yen, Jonathan,Li, Joanne,Ying, Hanze,Wang, Hua,Hua, Yuyan,Chaney, Eric J.,Boppart, Stephen A.,Cheng, Jianjun
, p. 6948 - 6951 (2015)
We developed a real-time drug-reporting ...
Oligonucleotide arrays from aldehyde-bearing glass with coated background
Dombi, Kendra L.,Griesang, Niels,Richert, Clemens
, p. 816 - 824 (2002)
Presented here is a method for preparing...
Targeting G Protein-Coupled Receptors with Magnetic Carbon Nanotubes: The Case of the A3 Adenosine Receptor
Pineux, Florent,Federico, Stephanie,Klotz, Karl-Norbert,Kachler, Sonja,Michiels, Carine,Sturlese, Mattia,Prato, Maurizio,Spalluto, Giampiero,Moro, Stefano,Bonifazi, Davide
supporting information, p. 1909 - 1920 (2020/09/11)
The A3 adenosine receptor (AR) is a G pr...
MULTI-ELECTRON REDOX-ACTIVE ORGANIC MOLECULES FOR HIGH-ENERGY-DENSITY NONAQUEOUS REDOX FLOW BATTERIES
-
Page/Page column 10-13, (2020/12/11)
The invention relates to 1,4-diaminoanth...
A halogen-bonding foldamer molecular film for selective reagentless anion sensing in water
Hein, Robert,Borissov, Arseni,Smith, Martin D.,Beer, Paul D.,Davis, Jason J.
supporting information, p. 4849 - 4852 (2019/05/02)
We describe self-assembled monolayers of...
Anion Recognition in Water by Charge-Neutral Halogen and Chalcogen Bonding Foldamer Receptors
Borissov, Arseni,Marques, Igor,Lim, Jason Y.C.,Félix, Vítor,Smith, Martin D.,Beer, Paul D.
supporting information, p. 4119 - 4129 (2019/03/07)
A novel strategy for the recognition of ...
74654-07-2 Process route
-
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74654-06-1,89485-61-0
2-(2-(2-methoxyethoxy)ethoxy)ethyl azide
-
![2-[2-(2-methoxyethoxy)ethoxy]ethylamine](/upload/2026/4/8c250ec232ea4b60a33b5177ce138f7c_4c5a26b2-bfca-48ea-9748-708cdc553990.png)
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74654-07-2,80506-64-5,869718-87-6
2-[2-(2-methoxyethoxy)ethoxy]ethylamine
| Conditions | Yield |
|---|---|
|
With
lithium aluminium tetrahydride;
In
diethyl ether;
at 20 ℃;
for 1h;
Inert atmosphere;
|
100%
|
|
With
lithium aluminium tetrahydride;
In
diethyl ether;
for 2h;
Ambient temperature;
|
99%
|
|
With
triphenylphosphine;
In
tetrahydrofuran;
at 20 ℃;
for 5h;
|
97%
|
|
With
palladium 10% on activated carbon; hydrogen;
In
ethanol;
for 5h;
under 2844.39 Torr;
|
87%
|
|
2-(2-(2-methoxyethoxy)ethoxy)ethyl azide;
With
triphenylphosphine;
In
tetrahydrofuran;
at 20 ℃;
for 0.0833333h;
With
water;
In
tetrahydrofuran;
at 20 ℃;
|
86%
|
|
2-(2-(2-methoxyethoxy)ethoxy)ethyl azide;
With
triphenylphosphine;
In
tetrahydrofuran;
Inert atmosphere;
With
water;
In
tetrahydrofuran;
Inert atmosphere;
|
84%
|
|
With
triphenylphosphine;
In
tetrahydrofuran;
at 20 ℃;
for 24h;
|
83.9%
|
|
2-(2-(2-methoxyethoxy)ethoxy)ethyl azide;
With
triphenylphosphine;
In
tetrahydrofuran;
at 20 ℃;
Inert atmosphere;
In
tetrahydrofuran; water;
at 20 ℃;
Inert atmosphere;
|
83%
|
|
With
platinum(IV) oxide; hydrogen;
In
methanol;
at 20 ℃;
under 760.051 Torr;
|
74%
|
|
With
triphenylphosphine;
In
diethyl ether; water;
at 20 ℃;
for 72h;
|
70%
|
|
2-(2-(2-methoxyethoxy)ethoxy)ethyl azide;
With
triphenylphosphine;
In
diethyl ether;
at 0 - 20 ℃;
for 2h;
Inert atmosphere;
With
water;
In
diethyl ether;
for 4h;
Inert atmosphere;
|
67%
|
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran; diethyl ether;
at 20 ℃;
for 1h;
|
67%
|
|
With
triphenylphosphine;
In
tetrahydrofuran;
at 20 ℃;
Inert atmosphere;
|
61%
|
|
2-(2-(2-methoxyethoxy)ethoxy)ethyl azide;
With
triphenylphosphine;
In
tetrahydrofuran;
at 20 ℃;
for 72h;
Inert atmosphere;
Cooling with ice;
With
water;
In
tetrahydrofuran;
at 20 ℃;
for 24h;
|
56%
|
|
With
water; triphenylphosphine;
In
tetrahydrofuran;
at 20 ℃;
for 4h;
|
51%
|
|
With
hydrogen;
palladium on activated charcoal;
In
methanol;
Ambient temperature;
|
|
|
With
water; triphenylphosphine;
Multistep reaction;
1.) THF, RT, 12 h, 2.) RT, 12 h;
|
|
|
With
hydrogen;
palladium on activated charcoal;
In
ethanol; chloroform;
under 3040.2 Torr;
|
|
|
2-(2-(2-methoxyethoxy)ethoxy)ethyl azide;
With
triphenylphosphine;
In
tetrahydrofuran;
Inert atmosphere;
With
water;
In
tetrahydrofuran;
Inert atmosphere;
|
|
|
With
palladium 10% on activated carbon; hydrogen;
In
ethanol;
for 5h;
under 2585.81 Torr;
|
|
|
2-(2-(2-methoxyethoxy)ethoxy)ethyl azide;
With
triphenylphosphine;
In
diethyl ether;
With
water;
In
diethyl ether;
|
|
|
With
palladium on activated charcoal; hydrogen;
In
ethanol;
for 24h;
under 2068.65 Torr;
Reagent/catalyst;
|
|
|
2-(2-(2-methoxyethoxy)ethoxy)ethyl azide;
With
triphenylphosphine;
In
diethyl ether;
at 0 - 20 ℃;
for 24h;
With
water;
In
diethyl ether;
for 12h;
|
|
|
With
triphenylphosphine;
In
tetrahydrofuran; water;
at 25 ℃;
for 22h;
|
|
|
With
methanol; sodium tetrahydroborate; copper(ll) sulfate pentahydrate;
at 0 ℃;
for 4.25h;
|
6.58 g
|
|
2-(2-(2-methoxyethoxy)ethoxy)ethyl azide;
With
triphenylphosphine;
In
diethyl ether;
at 0 - 20 ℃;
for 24h;
With
water;
In
diethyl ether;
for 12h;
|
-
-
62921-74-8,518012-62-9,58320-73-3
2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate
-
-
74654-07-2,80506-64-5,869718-87-6
2-[2-(2-methoxyethoxy)ethoxy]ethylamine
| Conditions | Yield |
|---|---|
|
2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate;
With
potassium phtalimide;
In
N,N-dimethyl-formamide;
at 120 ℃;
for 4h;
With
hydrazine hydrate;
In
ethanol;
for 6h;
Reflux;
|
86%
|
|
2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate;
With
sodium azide;
In
N,N-dimethyl-formamide;
at 67 ℃;
for 10h;
Inert atmosphere;
With
triphenylphosphine;
In
diethyl ether;
at 0 - 20 ℃;
for 2.5h;
|
82%
|
|
Multi-step reaction
with
2
steps
1: sodium azide / dimethylformamide / 12 h / 50 °C
2: 1.) PPh3
, 2.) H2
O / 1.) THF, RT, 12 h, 2.) RT, 12 h
With
sodium azide; water; triphenylphosphine;
In
N,N-dimethyl-formamide;
|
|
|
Multi-step reaction
with
2
steps
1.1: sodium azide / water; acetone / Inert atmosphere
2.1: triphenylphosphine / tetrahydrofuran / Inert atmosphere
2.2: Inert atmosphere
With
sodium azide; triphenylphosphine;
In
tetrahydrofuran; water; acetone;
|
|
|
Multi-step reaction
with
2
steps
1: sodium azide / N,N-dimethyl-formamide / 7 h / 100 °C
2: palladium 10% on activated carbon; hydrogen / ethanol / 5 h / 2844.39 Torr
With
sodium azide; palladium 10% on activated carbon; hydrogen;
In
ethanol; N,N-dimethyl-formamide;
|
|
|
Multi-step reaction
with
2
steps
1: sodium azide / N,N-dimethyl-formamide / 8 h / 100 °C / Inert atmosphere
2: palladium 10% on activated carbon; hydrogen / ethanol / 5 h / 2585.81 Torr
With
sodium azide; palladium 10% on activated carbon; hydrogen;
In
ethanol; N,N-dimethyl-formamide;
|
|
|
Multi-step reaction
with
2
steps
1.1: sodium azide / water; N,N-dimethyl-formamide / 16 h / 60 °C
2.1: triphenylphosphine / tetrahydrofuran / 72 h / 20 °C / Inert atmosphere; Cooling with ice
2.2: 24 h / 20 °C
With
sodium azide; triphenylphosphine;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
|
|
|
Multi-step reaction
with
2
steps
1.1: sodium azide / N,N-dimethyl-formamide / 36 h / 60 °C / Inert atmosphere
2.1: triphenylphosphine / tetrahydrofuran / Inert atmosphere
2.2: Inert atmosphere
With
sodium azide; triphenylphosphine;
In
tetrahydrofuran; N,N-dimethyl-formamide;
|
|
|
Multi-step reaction
with
2
steps
1.1: sodium azide / N,N-dimethyl-formamide / 23 h / 60 - 120 °C / Inert atmosphere
2.1: triphenylphosphine / diethyl ether / 2 h / 0 - 20 °C / Inert atmosphere
2.2: 4 h / Inert atmosphere
With
sodium azide; triphenylphosphine;
In
diethyl ether; N,N-dimethyl-formamide;
|
|
|
Multi-step reaction
with
2
steps
1: sodium azide / N,N-dimethyl-formamide / 12 h / 80 °C / Inert atmosphere
2: palladium on activated charcoal; hydrogen / ethanol / 24 h / 2068.65 Torr
With
sodium azide; palladium on activated charcoal; hydrogen;
In
ethanol; N,N-dimethyl-formamide;
|
|
|
Multi-step reaction
with
2
steps
1.1: sodium azide / N,N-dimethyl-formamide / 12 h / 67 °C / Inert atmosphere
2.1: triphenylphosphine / diethyl ether / 24 h / 0 - 20 °C
2.2: 12 h
With
sodium azide; triphenylphosphine;
In
diethyl ether; N,N-dimethyl-formamide;
|
|
|
Multi-step reaction
with
2
steps
1: sodium azide / water; acetone / 75 °C
2: triphenylphosphine / tetrahydrofuran / 5 h / 20 °C
With
sodium azide; triphenylphosphine;
In
tetrahydrofuran; water; acetone;
|
|
|
Multi-step reaction
with
2
steps
1: sodium azide / N,N-dimethyl-formamide / 12 h / Reflux
2: triphenylphosphine / water; diethyl ether / 72 h / 20 °C
With
sodium azide; triphenylphosphine;
In
diethyl ether; water; N,N-dimethyl-formamide;
2: |Staudinger Azide Reduction;
|
|
|
Multi-step reaction
with
2
steps
1: sodium azide / water; tetrahydrofuran / 7.5 h / 70 °C / Sealed tube
2: copper(ll) sulfate pentahydrate; sodium tetrahydroborate; methanol / 4.25 h / 0 °C
With
methanol; sodium tetrahydroborate; sodium azide; copper(ll) sulfate pentahydrate;
In
tetrahydrofuran; water;
|
|
|
Multi-step reaction
with
2
steps
1.1: sodium azide / water; acetone / Reflux
2.1: triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
With
sodium azide; triphenylphosphine;
In
tetrahydrofuran; water; acetone;
|
|
|
Multi-step reaction
with
2
steps
1.1: sodium azide / N,N-dimethyl-formamide / 12 h / 67 °C / Inert atmosphere
2.1: triphenylphosphine / diethyl ether / 24 h / 0 - 20 °C
2.2: 12 h
With
sodium azide; triphenylphosphine;
In
diethyl ether; N,N-dimethyl-formamide;
|
|
|
Multi-step reaction
with
2
steps
1: sodium azide / N,N-dimethyl-formamide / 5 h / 60 °C / Inert atmosphere
2: platinum(IV) oxide; hydrogen / methanol / 20 °C / 760.05 Torr
With
platinum(IV) oxide; sodium azide; hydrogen;
In
methanol; N,N-dimethyl-formamide;
|
74654-07-2 Upstream products
-
52995-76-3
1-chloro-3,6,9-trioxadecane
-
74654-06-1
2-(2-(2-methoxyethoxy)ethoxy)ethyl azide
-
167221-50-3
N-[2-(2-(2-methoxyethoxy)ethoxy)ethyl]phthalimide
-
112-35-6
triethylene glucol monomethyl ether
74654-07-2 Downstream products
-
70384-57-5
tris-(3,6,9-trioxadecyl)-amine
-
854601-58-4
CH3 (OCH2 CH2 )3-NH-13-cis-retinamide
-
253604-44-3
(SP-4-2)-([tetrakis[2-[2-(2-methoxyethoxy)ethoxy]ethyl] 4,4',4'',4'''-[10-(3,5-bis[[6-(1H-imidazol-1-yl)hexyl]oxy]-4-methylphenyl)-21H,23H-porphine-1,15-diylbis(benzene-2,1,3-triyldioxy)]tetrakis[butanamido]](2-) -N(21) ,N(22) ,N(23) ,N(24) )zinc(II)
-
1059587-93-7
mPEG3 -NH-diphenhydramine
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