Organic Chemicals
Product classification
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Factory supply 3-Oxobutanenitrile 2469-99-0 with sufficient production capacity
- Molecular Formula: C4H5NO
- Molecular Weight: 83.0898
- Vapor Pressure: 13.3mmHg at 25°C
- Refractive Index: 1.397
- Boiling Point: 123.5°C at 760 mmHg
- PKA: 10.31±0.10(Predicted)
- Flash Point: 28.5°C
- PSA： 40.86000
- Density: 0.976g/cm3
- LogP: 0.48908
3-Oxobutanenitrile(Cas 2469-99-0) Usage
InChI:InChI=1/C4H5NO/c1-4(6)2-3-5/h2H2,1H3
2469-99-0 Relevant articles
Kinetic Evidence for the Intermediacy of 1-Azirines in the Gas-Phase Thermal Isomerization of 3H-Isoxazoles to α-Carbonylacetonitrile Derivatives
Perez, Jorge D.,Yranzo, Gloria I.,Wunderlin, Daniel A.
, p. 982 - 984 (1982)
Thermal isomerization of 5-methylisoxazo...
Synthesis of some novel pyrazolo[3,4-b]pyridine and pyrazolo[3,4-d]pyrimidine derivatives bearing 5,6-diphenyl-1,2,4-triazine moiety as potential antimicrobial agents
El-Sayed Ali, Tarik
, p. 4385 - 4392 (2009)
The reaction of 5,6-diphenyl-3-hydrazino...
Design, synthesis, and in vitro anticancer screening of novel pyrazolinyl-pyrazole/1, 2, 3-triazole hybrids
Ismail, Magda M. F.,Abdulwahab, Hanan G.,Elnagdi, Mohamed H.
, p. 3584 - 3596 (2020)
Novel hybrids, pyrazolinylpyrazoles, and...
Synthesis of Novel 3-Acetyl-2-aminothiophenes and Investigation of their Behaviour in the Reaction with Vilsmeier-Haack Reagent
Abdelwahab, Ahmed B.,Hanna, Atef G.,Kirsch, Gilbert
, p. 2881 - 2888 (2016)
Through an investigation into the behavi...
AMIDITE COMPOUND AND METHOD FOR PRODUCING POLYNUCLEOTIDE USING SAID COMPOUND
-
Paragraph 0173-0174, (2021/08/06)
The present invention provides an amidit...
Identification of TRD-35 as Potent and Selective DRAK2 Inhibitor
Ali, Imran,Park, Sangjun,Jung, Myoung Eun,Lee, Nari,Bibi, Maimoona,Chae, Chong Hak,Yang, Kyung-Min,Kim, Seong-Jin,Choi, Gildon,Lee, Kwangho
, p. 567 - 569 (2020/03/23)
-
Identification of diphenylalkylisoxazol-5-amine scaffold as novel activator of cardiac myosin
Boggu, Pulla Reddy,Venkateswararao, Eeda,Manickam, Manoj,Sharma, Niti,Kang, Jong Seong,Jung, Sang-Hun
, (2020/09/16)
To identify novel potent cardiac myosin ...
2469-99-0 Process route
-
-
141-78-6
ethyl acetate
-
-
75-05-8,26809-02-9
acetonitrile
-
-
2469-99-0
Cyanoaceton
| Conditions | Yield |
|---|---|
|
With
n-butyllithium; diisopropylamine;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 2h;
Reagent/catalyst;
Inert atmosphere;
|
87%
|
|
With
sodium amide; benzene;
|
|
|
With
sodium;
|
|
|
With
sodium hydride;
In
1,4-dioxane;
|
|
|
ethyl acetate; acetonitrile;
With
potassium tert-butylate;
In
tetrahydrofuran;
at 20 ℃;
With
hydrogenchloride;
In
tetrahydrofuran; water;
pH=2;
|
|
|
With
sodium hydride;
In
tetrahydrofuran;
at 65 ℃;
for 12h;
|
|
|
With
n-butyllithium;
In
tetrahydrofuran;
at -78 - 20 ℃;
|
|
|
With
sodium hydride;
In
1,4-dioxane; mineral oil;
at 20 ℃;
for 16h;
|
|
|
With
sodium hydride;
In
toluene;
Reflux;
|
|
|
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 50 ℃;
|
-
-
79-20-9
acetic acid methyl ester
-
-
75-05-8,26809-02-9
acetonitrile
-
-
2469-99-0
Cyanoaceton
| Conditions | Yield |
|---|---|
|
With
n-butyllithium; diisopropylamine;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 2h;
Reagent/catalyst;
Inert atmosphere;
|
85%
|
|
With
potassium 2-methylbutan-2-olate;
In
tetrahydrofuran; toluene;
at 0 - 20 ℃;
Inert atmosphere;
|
81%
|
|
With
potassium tert-butylate;
In
tetrahydrofuran;
at 20 ℃;
|
|
|
With
potassium 2-methylbutan-2-olate;
In
tetrahydrofuran; toluene;
at 0 - 20 ℃;
for 78h;
|
2469-99-0 Upstream products
-
5765-44-6
5-methylisoxazole
-
141-52-6
sodium ethanolate
-
313048-10-1
but-2-ynal oxime
-
1118-61-2
3-Aminocrotononitrile
2469-99-0 Downstream products
-
42412-18-0
3-phenylhydrazono-butyronitrile
-
60930-93-0
1-bromo-1-cyanopropan-2-on
-
23340-25-2
α-benzal-β-ketobutyronitrile
-
16459-47-5
5-methyl-2-(4-nitrophenyl)-2H-pyrazol-3-ylamine
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