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Buy Good Quality 4-(4-Fluorophenyl)butanoic acid 589-06-0 with a minimum purity of 99%
- Molecular Formula: C10H11FO2
- Molecular Weight: 182.195
- Vapor Pressure: 0.000646mmHg at 25°C
- Melting Point: 45 °C
- Boiling Point: 296.5°C at 760mmHg
- PKA: 4.75±0.10(Predicted)
- Flash Point: 133.1°C
- PSA： 37.30000
- Density: 1.182g/cm3
- LogP: 2.23300
4-(4-Fluorophenyl)butanoic acid(Cas 589-06-0) Usage
|
General Description |
4-(4-Fluorophenyl)butanoic acid, also known as 4-fluoro-α-methylphenylbutyric acid, is a chemical compound with the molecular formula C10H11FO2. It is a derivative of butanoic acid and contains a fluorine-substituted phenyl group. This chemical is typically used in the pharmaceutical industry as an intermediate for the synthesis of various compounds, including medications and research chemicals. It has properties that make it useful for developing new drugs and studying their effects on the body. 4-(4-Fluorophenyl)butanoic acid is also known to have some potential as an antidepressant and anticonvulsant, making it an important compound for research and development in the medical field. |
InChI:InChI=1/C10H11FO2/c11-9-6-4-8(5-7-9)2-1-3-10(12)13/h4-7H,1-3H2,(H,12,13)/p-1
589-06-0 Relevant articles
Practical Synthesis of (3a R, 9b R)-8-Fluoro-7-(perfluoropropan-2-yl)-9b-(phenylsulfonyl)-2,3,3a,4,5,9b-hexahydro-1 H-benzo[e]indole: An Advanced Intermediate to Access the RORγt Inverse Agonist BMT-362265
Karmakar, Ananta,Nimje, Roshan Y.,Silamkoti, Arundutt,Pitchai, Manivel,Basha, Mushkin,Singarayer, Christuraj,Ramasamy, Duraisamy,Babu, G. T. Venkatesh,Samikannu, Ramesh,Subramaniam, Srinath,Anjanappa, Prakash,Vetrichelvan, Muthalagu,Kumar, Hemantha,Dikundwar, Amol G.,Gupta, Anuradha,Gupta, Arun Kumar,Rampulla, Richard,Dhar, T. G. Murali,Mathur, Arvind
, p. 1001 - 1014 (2021/04/12)
A practical and scalable route to (3aR, ...
Synthesis of Enantiopure ω-(4-Fluorophenyl)-6,11-Methylene Lipoxin B 4Methyl Ester
Trippe, Lukas,Nava, Analuisa,Frank, Andrea,Schollmeyer, Dieter,Nubbemeyer, Udo
supporting information, p. 3760 - 3768 (2021/06/28)
The synthesis of Lipoxin B 4analogues (L...
Ligand-Controlled Regiodivergence in Nickel-Catalyzed Hydroarylation and Hydroalkenylation of Alkenyl Carboxylic Acids**
Deng, Ruohan,Engle, Keary M.,Fu, Yue,Gao, Yang,Li, Zi-Qi,Liu, Peng,Tran, Van T.
supporting information, p. 23306 - 23312 (2020/10/19)
A nickel-catalyzed regiodivergent hydroa...
Synthesis of Novel Pterocarpen Analogues via [3?+?2] Coupling-Elimination Cascade of α,α-Dicyanoolefins with Quinone Monoimines
Chen, Hui,Zhao, Sihan,Cheng, Shaobing,Dai, Xingjie,Xu, Xiaoying,Yuan, Weicheng,Zhang, Xiaomei
, p. 1672 - 1683 (2019/04/08)
By employing triethylamine as a catalyst...
589-06-0 Process route
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127404-66-4
4-(4-fluorophenyl)but-3-enoic acid
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-
589-06-0
4-(4-fluorophenyl)butanoic acid
| Conditions | Yield |
|---|---|
|
With
palladium 10% on activated carbon; hydrogen;
In
ethanol;
for 3h;
under 3000.3 Torr;
Autoclave;
|
96%
|
|
With
hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran;
at 20 ℃;
for 3h;
under 760.208 Torr;
|
|
|
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
at 20 ℃;
|
-
-
366-77-8
4-(4-fluorophenyl)-4-oxopropionic acid
-
-
589-06-0
4-(4-fluorophenyl)butanoic acid
| Conditions | Yield |
|---|---|
|
palladium;
In
acetic acid;
|
97%
|
|
palladium;
In
acetic acid;
|
97%
|
|
palladium;
In
acetic acid;
|
97%
|
|
With
palladium on activated charcoal; hydrogen; acetic acid;
at 20 ℃;
for 16h;
under 7240.26 Torr;
Autoclave;
|
92%
|
|
With
hydrogenchloride; mercury; zinc;
In
toluene;
for 48h;
Heating;
|
85%
|
|
With
hydrazine hydrate; potassium hydroxide;
In
diethylene glycol;
at 120 - 200 ℃;
for 5h;
Dean-Stark;
|
35%
|
|
With
hydrogenchloride; amalgamated zinc; toluene;
weiteres Reagens: Essigsaeure;
|
|
|
With
hydrogenchloride; mercury; zinc;
In
toluene;
for 1h;
Ambient temperature;
|
|
|
With
hydrogenchloride; mercury; zinc;
|
|
|
(reduction);
|
|
|
With
perchloric acid; hydrogen; acetic acid;
palladium 10% on activated carbon;
|
|
|
With
amalgamated zinc; acetic acid;
In
water; toluene;
for 4h;
Reflux;
|
|
|
With
hydrogenchloride; zinc amalgam;
In
toluene;
Reflux;
|
|
|
With
palladium 10% on activated carbon; hydrogen;
In
acetic acid;
at 70 ℃;
|
|
|
With
hydrazine hydrate; potassium hydroxide;
In
ethylene glycol;
at 180 ℃;
for 10h;
|
|
|
With
hydrazine hydrate; potassium hydroxide;
In
ethylene glycol;
at 130 ℃;
for 5h;
Reflux;
|
589-06-0 Upstream products
-
366-77-8
4-(4-fluorophenyl)-4-oxopropionic acid
-
3200-99-5
4-[4-(4-fluoro-phenyl)-butyryl]-thiomorpholine
-
1117-71-1
methyl 4-bromocrotonate
-
17151-47-2
tributyl(4-fluorophenyl)stannane
589-06-0 Downstream products
-
20637-05-2
methyl 4-(4-fluorophenyl)butanoate
-
2840-44-0
7-fluoro-3,4-dihydronaphthalen-1(2H)-one
-
1693-05-6
ethyl 4-(4'-fluorophenyl)butanoate
-
133188-66-6
4-(4-fluorophenyl)butyryl chloride
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